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Mad-Cow Disease

Mad-cow disease, also known as bovine spongiform encephalopathy (the spongiform is for sponge, as in "this disease will chew holes in your brain until it looks like a sponge"), first came to the public's attention in the mid-1990s, when the illness, caused by deformed protein fragments called prions, made the jump from cows to humans.
Known in humans as variant Creutzfeldt-Jakob disease, the illness is spread through contaminated meat and causes a host of awful degenerative neurological symptoms, including dementia, loss of nervous system and muscle control, and eventually, death.
And as if the idea of your brain slowly turning to Swiss cheese isn't gross enough, its path to prominence is also disgusting.
The dangerous prion spread to outbreak proportions due to the then-common cannibalistic practice of feeding diseased cattle remains (including bone and brain, complete with BSE prions) to other cattle, which were then consumed by humans. Now, that's just wrong.

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