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Rabies

Foaming at the mouth, difficulty swallowing, a maniacal fear of water, anger and hostility, delusions and hallucinations, general all-round insanity.
You may recognize these symptoms from that pack of rabid raccoons in your backyard, but a couple of hundred years ago, a lot more humans found themselves acting like those unfortunate animals.
Back before Louis Pasteur's groundbreaking vaccine hit the scene in 1885, rabies was a widely feared disease (and it still is in some parts of the world). Spread through saliva (usually through dog bites), the rabies virus attacks the nervous system; once it's gotten to your brain, it's pretty much over.
Today, mandatory animal vaccination programs have pretty much wiped out the disease in humans in the developed world, but the disease still kills millions of animals and up to 50,000 people worldwide each year. Consider that a reminder to vaccinate Fluffy.

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